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Vitamin C (ascorbic acid)
Posted by Admin on 16-03-2014 at 12:35 pm Under Chemistry Cafe

Vitamin C (ascorbic acid) is a substance that has been closely studied throughout history by many people. There have been many different experiments carried out to observe the effects of this substance. One such investigation was carried out in the department of Food Science and Microbiology, in the University of Milan by Serena Guarnieri, Patrizia Riso and Marisa Porrini.

Vitamin C seems to be the most effective antioxidant, as demonstrated in vitro studies (Szeto et al. 2002; Proteggente et al. 2002). Many in vivo studies have investigated the role of vitamin C in the protection against oxidative-induced DNA damage: single-dose trials showed significant antioxidant protection (Green et al. 1994; Panayiotidis & Collins, 1997. )

The ingestion of fruits abundant in vitamin C appears to increase the antioxidant defense of the organism. In spite of this, it is still not apparent whether vitamin C is the only substance responsible for this effect. The aim of this investigation was to study the effect of the ingestion of a single portion of blood orange juice (BOJ, 300 ml, providing 150 mg vitamin C) on mononuclear blood cell (MNBC) DNA damage, compared with a drink supplemented with the same amount of vitamin C (C-drink) or sugars (S-drink). Seven young healthy subjects were randomly selected in a repeated-measures design in which they received each drink on different occasions, 2 weeks apart. Blood samples were collected at baseline, every hour to 8 hour, and at 24 hour after the intake of each drink. The Vitamin C was analyzed at each time. Plasma vitamin C concentration increased similarly following BOJ or C-drink intake and was not affected by the S-drink. No effect of the C-drink and S-drink was observed. In conclusion, the intake of a single portion of BOJ provided an early protection of MNBC against oxidative DNA damage; however, the protective effect of BOJ was not explained by vitamin C alone, thus other phytochemicals could be involved.



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